Searchable abstracts of presentations at key conferences in endocrinology

Endocrine Abstracts

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ea0084ps3-12-109 | Graves’ Disease 2 and Orbitopathy | ETA2022

Blocking the TSH receptor with human monoclonal autoantibody K1-70TM in patients with graves’ disease – results from a phase 1 clinical trial

Furmaniak Jadwiga , Sanders Jane , Sanders Paul , Li Yang , Rees Smith Bernard

Objectives: TSH receptor (TSHR) autoantibodies (TRAb) which mimic the actions of TSH are responsible for hyperthyroidism in Graves’ disease (GD) which is often associated with Graves’ orbitopathy (GO). K1-70 is a TSHR specific human monoclonal autoantibody which binds to the TSHR with high affinity and prevents stimulation of the TSHR by TSH and TRAb. Safety, tolerability, pharmacokinetic, pharmocodynamic and immunogenic effects of K1-70 in patients with GD were asse...
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ea0094ja5 | Society for Endocrinology Journal Award – Clinical Endocrinology | SFEBES2023

TSH receptor specific monoclonal autoantibody K1-70TM targeting of the TSH receptor in subjects with Graves' disease and Graves' orbitopathy-Results from a phase I clinical trial

Furmaniak, Jane Sanders, Paul Sanders, Yang Li, Bernard Rees Smith Jadwiga

Clin Endocrinology (Oxf), 2022, 96, 878-887 (DOI: https://doi.org/10.1111/cen.14681): ...
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ea0063oc4.5 | Thyroid 1 | ECE2019

A comprehensive assessment of the interplay between the thyroid function and the immune system: results from the Human Functional Genomics Project

Sloot Yvette , Jaeger Martin , Ter Horst Rob , Chu Xiaojing , Koenen Hans , Joosten Irma , Moorlag Simone , Mourits Vera , De Bree Charlotte , Koeken Valerie , van Herwaarden Antonius , Li Yang , Smit Jan , Netea Mihai , Netea-Maier Romana

Background: Accumulating evidence indicates the presence of bidirectional cross-talks between the endocrine and the immune system. However, no data are available on the influence of either the thyroid hormones or TSH within the normal range on the immune cell function in healthy humans.Aim: To comprehensively investigate the effects of the hypothalamic-pituitary-thyroid axis on the variation of immune responses in a cohort of healthy volunteers.<p cl...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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